Noggin Elicits Retinal Fate in Xenopus Animal Cap Embryonic Stem Cells
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چکیده
منابع مشابه
17-P030 Noggin elicits retinal fate in Xenopus animal cap embryonic stem cells
Driving specific differentiation pathways in multipotent stem cells is a main goal of cell therapy. Here we exploited the differentiating potential of Xenopus animal cap embryonic stem (ACES) cells to investigate the factors necessary to drive multipotent stem cells toward retinal fates. ACES cells are multipotent, and can be diverged from their default ectodermal fate to give rise to cell type...
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In this review we examine the potential of embryonic stem cells (ESCs) for use in the treatment of retinal diseases involving photoreceptors and retinal pigment epithelium (RPE). We outline the ontogenesis of target retinal cell types (RPE, rods and cones) and discuss how an understanding of developmental processes can inform our manipulation of ESCs in vitro. Due to their potential for cellula...
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Grafting, together with tissue identification by monoclonal antibodies, has been used to study the allocation of Xenopus animal cap cells to the ectodermal or mesodermal lineages. Animal cap cells become responsive at stage 61 and lose responsiveness to mesodermal induction at, or just after, stage 10i (depending on the batch of embryos). The ability of the vegetal yolky cells to induce mesoder...
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7 2 ABSTRACT The molecular signals specifying neuronal, glial or multipotent precursors in the developing and adult central nervous system (CNS) are largely unknown. Radial glial cells have recently been discovered as major precursor population generating neurons or glial cells in separate lineages in the developing CNS. Towards this aim to identify the key molecular determinants for neurogenic...
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ژورنال
عنوان ژورنال: STEM CELLS
سال: 2009
ISSN: 1066-5099
DOI: 10.1002/stem.167